Inventors:
Joseph Epstein - Baltimore MD
Harry O. Michel - Towson MD
Robert E. Plapinger - Baltimore MD
Joseph H. Fleisher - Baltimore MD
John J. Callahan - Baltimore MD
Bernard J. Jandorf - Baltimore MD
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
C07F 902
Abstract:
The compounds of S-(2-dialkylaminoalkyl) alkyl phosphonothioic acids and hod of preparing said compounds possessing anticholinesterase activity comprising an aqueous solution which comprises dialkylaminoalkyl chloride salts which are converted to their corresponding dialkylmonoalkyl ammonium ions and alkylphosphonothioic acids forming a reaction mixture. The latter mixture is placed on a cation exchange resin with subsequent addition of water as an eluting agent giving rise to fractions containing the desired compounds.
