Inventors:
David M. Goldenberg - Mendham NJ, US
Hans J. Hansen - Picayune MS, US
Chien-Hsing Ken Chang - Downingtown PA, US
Sailaja S. Vanama - Monroe NJ, US
Edmund A. Rossi - Nutley NJ, US
Assignee:
Immunomedics, Inc. - Morris Plains NJ
International Classification:
C07K 16/46
C07K 16/28
C07K 16/30
C12P 21/08
A61K 39/00
A61K 39/395
C12N 9/22
US Classification:
4241331, 4241341, 4241431, 4241561, 4241921, 4242361, 424199, 424328, 5303873, 53038822, 53038885, 530350
Abstract:
Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may be used in a variety of therapeutic methods for treating diseases or syndromes associated with unwanted or inappropriate cell proliferation or activation.