Sarah M Taylor

20220236258, Jul 28, 2022

Apr 8, 2022

17/716134

- Pleasanton CA, US
Sarah TAYLOR - Pleasanton CA, US
Stephane Claude BOUTET - Pleasanton CA, US
Wyatt James MCDONNELL - Pleasanton CA, US
Michael John Terry STUBBINGTON - Cambridge, GB

G01N 33/543

Provided herein are methods and systems for measuring secreted cytokines or other analytes from single cells. The methods disclosed herein include the use of analyte-specific and/or barcoded binding agents (e.g., antibodies) and beads in partitions (e.g., droplets or wells) to measure such analytes on a single cell basis. Further described herein are methods comprising the use of hydrogel-encapsulated cells (e.g., cell beads) to measure secreted and/or cellular analytes from single cells.

20220228220, Jul 21, 2022

Aug 31, 2021

17/462712

- Pleasanton CA, US
Michael Ybarra Lucero - Pleasanton CA, US
Elliott Meer - Pleasanton CA, US
Tarjei Sigurd Mikkelsen - Pleasanton CA, US
Katherine Pfeiffer - Pleasanton CA, US
Sarah Taylor - Pleasanton CA, US
Niranjan Srinivas - Pleasanton CA, US

C12Q 1/6886
C12N 15/10
G16B 30/00
G16B 50/00
C12Q 1/6881
C12Q 1/6804

The present disclosure provides methods, systems, and compositions for parallel processing of nucleic acid samples. Methods and systems of the present disclosure comprise the use of sample-specific barcode sequences, which facilitate the multiplexing of samples, detection of discrete cell populations within a pooled population, and detection of partitions comprising more than one cell.

20210372998, Dec 2, 2021

Mar 22, 2021

17/209045

- Pleasanton CA, US
Jason Bell - Palo Alto CA, US
Zachary Bent - Pleasanton CA, US
Rajiv Bharadwaj - Pleasanton CA, US
Christopher Hindson - Livermore CA, US
Bill Kengli Lin - Pleasanton CA, US
Anthony Makarewicz - Livermore CA, US
Geoffrey McDermott - Livermore CA, US
Elliott Meer - Pleasanton CA, US
Francesca Meschi - Menlo Park CA, US
Tarjei Sigurd Mikkelsen - Dublin CA, US
Christopher Joachim O'Keeffe - Pleasanton CA, US
Katherine Pfeiffer - Pleasanton CA, US
Andrew D. Price - Hayward CA, US
Paul Ryvkin - San Jose CA, US
Sarah Taylor - Fremont CA, US
Jessica Michele Terry - Pleasanton CA, US
Tobias Daniel Wheeler - Alameda CA, US
Yifeng Yin - Elk Grove CA, US
Xinying Zheng - San Jose CA, US
Solongo Batjargal Ziraldo - San Ramon CA, US
Eswar Prasad Ramachandran Iyer - Sunnyvale CA, US
Luigi Jhon Alvarado Martinez - Pleasanton CA, US

G01N 33/532
C07K 14/74
C12N 15/85
G01N 33/543
G01N 33/548
C12N 15/10
C12Q 1/6804
C12Q 1/6806
G01N 33/50
G01N 33/53
G01N 33/58
C12Q 1/6818
C12Q 1/6827
C12Q 1/6881
C12N 15/11
G01N 33/569

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and antigen screening. Polynucleotide processing may be useful for a variety of applications. Antigen screening may comprise the use of one or more engineered cells. Engineered cells may be useful for characterizing one or more analytes including, for example, a polypeptide antigen.

20210130892, May 6, 2021

Oct 29, 2020

17/084481

- Pleasanton CA, US
Zachary Bent - Pleasanton CA, US
Rajiv Bharadwaj - Pleasanton CA, US
Vijay Kumar Sreenivasa Gopalan - Pleasanton CA, US
Josephine Harada - San Francisco CA, US
Christopher Hindson - Livermore CA, US
Michael Ybarra Lucero - South San Francisco CA, US
Geoffrey McDermott - Livermore CA, US
Elliott Meer - Pleasanton CA, US
Tarjei Sigurd Mikkelsen - Dublin CA, US
Christopher Joachim O'Keeffe - Pleasanton CA, US
Katherine Pfeiffer - Berkeley CA, US
Andrew D. Price - Hayward CA, US
Paul Ryvkin - San Jose CA, US
Serge Saxonov - Oakland CA, US
John R. Stuelpnagel - Santa Barbara CA, US
Jessica Michele Terry - Pleasanton CA, US
Tobias Daniel Wheeler - Alameda CA, US
Indira Wu - San Carlos CA, US
Solongo Batjargal Ziraldo - San Ramon CA, US
Stephane Claude Boutet - Burlingame CA, US
Sarah Taylor - Pleasanton CA, US
Niranjan Srinivas - Dublin CA, US

C12Q 1/6874
C12Q 1/683
C12Q 1/6806

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.

20210102936, Apr 8, 2021

Jun 9, 2020

16/897126

- Pleasanton CA, US
Jason Bell - Palo Alto CA, US
Zachary Bent - Pleasanton CA, US
Rajiv Bharadwaj - Pleasanton CA, US
Christopher Hindson - Livermore CA, US
Bill Lin - Pleasanton CA, US
Anthony Makarewicz - Livermore CA, US
Geoffrey McDermott - Livermore CA, US
Elliott Meer - Pleasanton CA, US
Francesca Meschi - Menlo Park CA, US
Tarjei Sigurd Mikkelsen - Dublin CA, US
Christopher Joachim O'Keeffe - Pleasanton CA, US
Katherine Pfeiffer - Berkeley CA, US
Andrew D. Price - Hayward CA, US
Paul Ryvkin - San Jose CA, US
Sarah Taylor - Fremont CA, US
Jessica Michele Terry - Pleasanton CA, US
Tobias Daniel Wheeler - Alameda CA, US
Yifeng Yin - Elk Grove CA, US
Xinying Zheng - San Jose CA, US
Solongo Batjargal Ziraldo - San Ramon CA, US
Eswar Prasad Ramachandran Iyer - Sunnyvale CA, US
Luigi Jhon Alvarado Martinez - Pleasanton CA, US

G01N 33/532
C07K 14/74
C12N 15/85
G01N 33/543
G01N 33/548
C12N 15/10
C12Q 1/6804
C12Q 1/6806
G01N 33/50
G01N 33/53
G01N 33/58
C12Q 1/6818
C12Q 1/6827
C12Q 1/6881
C12N 15/11
G01N 33/569

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins) and chromatin (e.g., accessible chromatin).

20200339978, Oct 29, 2020

Feb 13, 2018

16/465134

- Mountain View CA, US
Ishminder MANN - Milpitas CA, US
Andrew Alan FARMER - Los Altos CA, US
Sarah TAYLOR - Sunnyvale CA, US

C12N 15/10
C12Q 1/6853

Methods of preparing nucleic acid libraries are provided. Aspects of the methods include producing one or more libraries, including e.g., expression libraries and/or immune cell receptor repertoire libraries, from double stranded complementary DNA (cDNA) generated through a template-switching reaction involving a RNA sample. In some aspects, the methods include preparing a library from a single cell and/or a library indexed at the single cell level. Compositions and kits for use in performing the methods are also provided.

20200002763, Jan 2, 2020

Jun 12, 2019

16/439675

- Pleasanton CA, US
Zachary Bent - Pleasanton CA, US
Rajiv Bharadwaj - Pleasanton CA, US
Vijay Kumar Sreenivasa Gopalan - Pleasanton CA, US
Josephine Harada - San Francisco CA, US
Christopher Hindson - Livermore CA, US
Michael Ybarra Lucero - South San Francisco CA, US
Geoffrey McDermott - Livermore CA, US
Elliott Meer - Pleasanton CA, US
Tarjei Sigurd Mikkelsen - Dublin CA, US
Christopher Joachim O'Keeffe - Pleasanton CA, US
Katherine Pfeiffer - Berkeley CA, US
Andrew D. Price - Hayward CA, US
Paul Ryvkin - San Jose CA, US
Serge Saxonov - Oakland CA, US
John R. Stuelpnagel - Santa Barbara CA, US
Jessica Michele Terry - Pleasanton CA, US
Tobias Daniel Wheeler - Alameda CA, US
Indira Wu - San Carlos CA, US
Solongo Batjargal Ziraldo - San Ramon CA, US
Stephane Claude Boutet - Pleasanton CA, US
Sarah Taylor - Pleasanton CA, US
Niranjan Srinivas - Dublin CA, US

C12Q 1/6874
C12Q 1/683
C12Q 1/6806

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.

20200002764, Jan 2, 2020

Jun 17, 2019

16/443638

- Pleasanton CA, US
Zachary Bent - Pleasanton CA, US
Rajiv Bharadwaj - Pleasanton CA, US
Vijay Kumar Sreenivasa Gopalan - Pleasanton CA, US
Josephine Harada - San Francisco CA, US
Christopher Hindson - Livermore CA, US
Michael Ybarra Lucero - South San Francisco CA, US
Geoffrey McDermott - Livermore CA, US
Elliott Meer - Pleasanton CA, US
Tarjei Sigurd Mikkelsen - Dublin CA, US
Christopher Joachim O'Keeffe - Pleasanton CA, US
Katherine Pfeiffer - Berkeley CA, US
Andrew D. Price - Hayward CA, US
Paul Ryvkin - San Jose CA, US
Serge Saxonov - Oakland CA, US
John R. Stuelpnagel - Santa Barbara CA, US
Jessica Michele Terry - Pleasanton CA, US
Tobias Daniel Wheeler - Alameda CA, US
Indira Wu - San Carlos CA, US
Solongo Batjargal Ziraldo - San Ramon CA, US
Stephane Claude Boutet - Burlingame CA, US
Sarah Taylor - Pleasanton CA, US
Niranjan Srinivas - Dublin CA, US

C12Q 1/6874
C12Q 1/683
C12Q 1/6806

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.