Search

Srikumar P Chellappan

from Tampa, FL
Age ~65
Get Report
Also known as:
Srikumar Chellapan, Srik Chellappan, Jaya Chellappan, Srik Freeman, Srik N
Phone and address:
10204 Quails Landing Ave, Tampa, FL 33647
(813) 907-1250
Related to:
Jaya Padmanabhan, 65
Connected to:
Arun Chellappa, 43Arune D Chellaram, 33Bomi S Chellaswami, 60Jayashree Chellappa, 57Kalaiselvi Chellappan, 45Paulraj Chellappa, 49Sangeeth S Chellappa, 49Sowmya Chellapilla, 43Subash Chellappan, 43Washington C Chelle, 41

Srikumar Chellappan Phones & Addresses

  • 10204 Quails Landing Ave, Tampa, FL 33647 (813) 907-1250 (813) 973-9088
  • 8801 Hunters Lake Dr, Tampa, FL 33647 (813) 907-1250
  • Tampa Palms, FL
  • 110 Madison Ave, Cresskill, NJ 07626 (201) 569-0774
  • Keysville, VA
  • Melba, ID
  • Rutland, VT
  • Durham, NC

Resumes

Resumes

Srikumar Chellappan Photo 1

Professor And Chair At H. Lee Moffitt Cancer Center & Research Institute

View page
Position:
Professor and Chair at H. Lee Moffitt Cancer Center & Research Institute
Location:
Tampa/St. Petersburg, Florida Area
Industry:
Higher Education
Work:
H. Lee Moffitt Cancer Center & Research Institute since Jul 2001
Professor and Chair
Columbia University Oct 1992 - Jul 2001
Asst. Professor
Duke University Medical Center - Durham, NC. Oct 1987 - Oct 1992
Post-doctoral Fellow & Res. Asst Professor
Education:
Indian Institute of Science 1981 - 1987
Ph.D., Biochemistry University of Kerala 1976 - 1981
B.Sc, M.Sc., Zoology
Skills:
Cancer
Molecular Biology
Biochemistry
Cancer Research
Cell Biology
Genetics
Drug Discovery
Genomics
Lifesciences
Western Blotting
In Vivo
Cell Culture
Signal Transduction
PCR
Cell Signaling
Science
Animal Models
Immunology
Biotechnology
Cell
Honor & Awards:
Prof. N.G. Kurup and Prof. Bhaskaran Nair Gold Medals for obtaining first rank in University of Kerala M.Sc. Zoology exams. Prof. Giri Memorial Gold Medal for best Ph.D. thesis in Biochemistry Department, Indian Institute of Science, 1987. Moffitt Cancer Center Research Scientist of the Year, 2007.
Srikumar Chellappan Photo 2

Professor And Chair

View page
Location:
Tampa, FL
Industry:
Higher Education
Work:
Columbia University In the City of New York Oct 1992 - Jul 2001
Assistant Professor
Moffitt Cancer Center Oct 1992 - Jul 2001
Professor and Chair
Duke University Medical Center Oct 1987 - Oct 1992
Post-Doctoral Fellow and Res Assistant Professor
Education:
Indian Institute of Science (Iisc) 1981 - 1987
Doctorates, Doctor of Philosophy, Biochemistry University of Kerala 1976 - 1981
Master of Science, Masters, Bachelors, Bachelor of Science, Zoology Govt Model (Boys) Higher Secondary School, Thycaud
Govt. Arts College, Trivandrum
University College, Thiruvananthapuram
Indian Institute of Science
Skills:
Cancer
Drug Discovery
Molecular Biology
Cell Biology
Cancer Research
Biochemistry
Signal Transduction
Oncology
Immunohistochemistry
Cell Culture
Life Sciences
Animal Models
Western Blotting
Biotechnology
Science
Cell
Cell Signaling
Pcr
Genetics
Immunoprecipitation
Functional Genomics
In Vivo
Immunology
Genomics
Translational Research
Molecular Genetics
Transfection
Biology
Protein Expression
Protein Chemistry
Flow Cytometry
Microscopy
Stem Cells
Tissue Culture
Lifesciences
Rt Pcr
Confocal Microscopy
In Vitro
Qpcr
Proteomics
Scientific Writing
Microarray Analysis
Epigenetics
Leadership
Protein Purification
Dna Sequencing
Bioinformatics
Dna
Microbiology
Molecular Cloning

Publications

Us Patents

Inhibition Of Cell Proliferation

View page
US Patent:
8642278, Feb 4, 2014
Filed:
Nov 22, 2006
Appl. No.:
11/562903
Inventors:
Said M. Sebti - Tampa FL, US
Srikumar Chellappan - Tampa FL, US
Nicholas James Lawrence - Tampa FL, US
Assignee:
University of South Florida - Tampa FL
International Classification:
A61K 31/155
A61K 31/215
A61K 31/34
A61K 31/41
A61K 31/415
A61K 31/425
A61K 31/44
A61K 31/47
A61K 31/675
C07D 233/00
C07D 249/12
US Classification:
435 723, 435375, 514311, 514349, 514370, 514384, 514385, 514395, 514470, 514508, 514634, 514 92, 546152, 546331, 548111, 548112, 548190, 5482632, 5483164, 549443, 558 4, 564237
Abstract:
The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with ICvalues ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.

Inhibition Of Cell Proliferation

View page
US Patent:
20100184851, Jul 22, 2010
Filed:
Aug 31, 2009
Appl. No.:
12/551262
Inventors:
Said M. Sebti - Tampa FL, US
Srikumar Chellappan - Tampa FL, US
Nicholas James Lawrence - Tampa FL, US
Assignee:
University of South Florida - Tampa FL
International Classification:
A61K 31/155
C07C 335/32
C07D 317/60
A61K 31/36
A61P 35/00
C12N 5/00
US Classification:
514466, 558 4, 514508, 549442, 435375
Abstract:
Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided.

Methods Using Hdac11 Inhibitors

View page
US Patent:
20190084946, Mar 21, 2019
Filed:
Nov 28, 2018
Appl. No.:
16/202210
Inventors:
- Watertown MA, US
- Tampa FL, US
Srikumar Chellappan - Tampa FL, US
Nicholas Barczak - Waterford CT, US
Jaime A. Escobedo - Natick MA, US
Chiara Conti - Belmont MA, US
Bingsong Han - Westwood MA, US
Cuixian Liu - Madison CT, US
Matthew W. Martin - Arlington MA, US
Pui Yee Ng - Waltham MA, US
Aleksandra Rudnitskaya - Roslindale MA, US
Jennifer R. Thomason - Clinton MA, US
Xiaozhang Zheng - Lexington MA, US
International Classification:
C07D 263/58
C07D 401/04
C07C 53/06
C07D 235/30
C07D 221/20
C07D 209/54
C07D 209/40
A61K 45/06
A61K 31/5383
A61K 31/5377
A61K 31/52
A61K 31/506
A61K 31/4985
A61K 31/4709
A61K 31/4439
A61K 31/438
A61K 31/437
A61K 31/435
A61K 31/428
C07D 498/04
C07D 491/107
C07D 491/056
C07D 487/04
C07D 473/00
C07D 417/06
C07D 413/14
C07D 413/12
C07D 413/06
C07D 405/04
C07D 403/06
C07D 403/04
C07D 401/14
C07D 401/06
A61K 31/427
A61K 31/4245
A61K 31/423
A61K 31/422
A61K 31/4192
A61K 31/4188
A61K 31/4184
A61K 31/4178
A61K 31/404
A61K 31/403
A61P 35/00
C07D 277/82
Abstract:
The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.

Methods Using Hdac11 Inhibitors

View page
US Patent:
20180127386, May 10, 2018
Filed:
Oct 20, 2017
Appl. No.:
15/789869
Inventors:
- Watertown MA, US
- Tampa FL, US
Srikumar Chellappan - Tampa FL, US
Nicholas Barczak - Waterford CT, US
Jaime A. Escobedo - Natick MA, US
Chiara Conti - Belmont MA, US
Bingsong Han - North Haven CT, US
Cuixian Liu - Madison CT, US
Matthew W. Martin - Arlington MA, US
Pui Yee Ng - Waltham MA, US
Aleksandra Rudnitskaya - Roslindale MA, US
Jennifer R. Thomason - Clinton MA, US
Xiaozhang Zheng - Lexington MA, US
International Classification:
C07D 263/58
A61P 35/00
A61K 31/423
C07D 413/12
A61K 31/4439
A61K 31/506
C07D 277/82
A61K 31/428
C07D 235/30
A61K 31/4184
C07C 53/06
C07D 209/40
A61K 31/404
C07D 473/00
A61K 31/52
C07D 487/04
A61K 31/4985
C07D 498/04
A61K 31/437
C07D 491/056
A61K 31/4188
A61K 31/5383
C07D 401/04
A61K 31/4709
C07D 405/04
A61K 31/4178
C07D 403/04
A61K 31/5377
C07D 209/54
A61K 31/403
C07D 413/06
A61K 31/422
C07D 401/14
C07D 401/06
C07D 413/14
A61K 31/4245
C07D 417/06
A61K 31/427
C07D 403/06
A61K 31/4192
C07D 221/20
A61K 31/438
C07D 491/107
A61K 31/435
A61K 45/06
Abstract:
The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.

Inhibition Of Cell Proliferation

View page
US Patent:
20140221658, Aug 7, 2014
Filed:
Feb 3, 2014
Appl. No.:
14/171273
Inventors:
- Tampa FL, US
Srikumar Chellappan - Tampa FL, US
Nicholas James Lawrence - Tampa FL, US
Assignee:
University of South Florida - Tampa FL
International Classification:
C07C 323/45
C07D 213/53
C07D 215/12
C07D 235/28
C07D 277/40
C07D 249/12
C07D 249/14
C07D 233/84
C07D 317/58
C07C 279/06
US Classification:
546176, 564244, 549464, 564247, 564246, 546331, 552290, 564237, 548199, 548190, 5482642, 5482644, 5483251, 5483071
Abstract:
The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with ICvalues ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.
Control profile
Srikumar P Chellappan from Tampa, FL, age ~65 Get Report