Inventors:
Venkata R. Garigapati - Southborough MA, US
Dongling Su - Franklin MA, US
Rehan Khanzada - Middleborough MA, US
Steven J. Sawamura - Newark CA, US
Assignee:
Advanced Technogies and Regenerative Medicine, LLC - Raynham MA
International Classification:
A61K 38/00
A61K 38/16
A61K 38/17
A61K 38/18
US Classification:
514 76, 514 88, 514 89, 514 167, 514 168, 514 169, 514 171, 514 172, 424422, 424423
Abstract:
The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.