Resumes
Resumes
Tzu Loh Phones & Addresses
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Campbell, CA
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Watertown, MA
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Somerville, MA
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Schaumburg, IL
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Cambridge, MA
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Ann Arbor, MI
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27A Oliver St, Watertown, MA 02472
Publications
Us Patents
Monitoring Heparin By Microelectronic Devices
View pageUS Patent:
20070212786, Sep 13, 2007
Filed:
Sep 29, 2006
Appl. No.:
11/540695
Inventors:
Scott Manalis - Cambridge MA, US
Tzu Loh - Watertown MA, US
Michel Godin - Somerville MA, US
Nebojsa Milovic - Basel, CH
Jonathan Behr - Cambridge MA, US
Aarthi Chandrasekaran - Cambridge MA, US
Ram Sasisekharan - Cambridge MA, US
Tzu Loh - Watertown MA, US
Michel Godin - Somerville MA, US
Nebojsa Milovic - Basel, CH
Jonathan Behr - Cambridge MA, US
Aarthi Chandrasekaran - Cambridge MA, US
Ram Sasisekharan - Cambridge MA, US
International Classification:
G01N 33/86
US Classification:
436069000
Abstract:
In one aspect, the present invention provides a device and method for real-time, direct detection of heparin in buffer and in serum comprising a microfluidic field-effect device as an affinity biosensor. The sensor is based on an electrolyte-insulator-silicon structure, and is manufactured by a standard high-yield silicon microfabrication process. The binding of heparin to the sensor surface induces a change in the insulator-electrolyte surface potential, which is measured as a change in sensor capacitance. To ensure the binding selectivity, protamine and antithrombin III are used as affinity probes.