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Valerie M Clerin

from Lexington, MA
Age ~52
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Connected to:
Willy Clerister, 54Elimelec M Clerjeune, 33Jacky Clerjuste, 45Josue M Clerjuste, 58Amyann M Clerk, 63Andrea J Clerk, 56Artee Clerk, 80Authur Clerk, 71Ivan R Clerk, 41Kevin L Clerk, 67

Valerie Clerin Phones & Addresses

  • Lexington, MA
  • 32 Hardy Ave, Watertown, MA 02472
  • 32 Hardy Ave #2, Watertown, MA 02472
  • 33 Merrill Rd, Watertown, MA 02472
  • 10 Summer St, Malden, MA 02148
  • Philadelphia, PA

Publications

Us Patents

Inhibitors Of Cytosolic Phospholipase A

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US Patent:
7557135, Jul 7, 2009
Filed:
May 26, 2006
Appl. No.:
11/442199
Inventors:
John C. McKew - Arlington MA, US
Katherine L. Lee - Newton MA, US
Lihren Chen - Bedford MA, US
Richard Vargas - Brighton MA, US
James D. Clark - Acton MA, US
Cara Williams - Methuen MA, US
Valerie Clerin - Watertown MA, US
Suzana Marusic - Reading MA, US
Kevin Pong - Robbinsville NJ, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/404
C07D 209/14
US Classification:
514415, 548507
Abstract:
This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase Aenzymes (cPLA), more particularly including inhibitors of cytosolic phospholipase Aalpha enzymes (cPLAα). In some embodiments, the inhibitors have the Formula I:.

Methods For The Use Of Inhibitors Of Cytosolic Phospholipase A2

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US Patent:
7605156, Oct 20, 2009
Filed:
May 27, 2005
Appl. No.:
11/140390
Inventors:
John C. McKew - Arlington MA, US
Steve Y. Tam - Wellesley MA, US
Katherine L. Lee - West Newton MA, US
Lihren Chen - Cambridge MA, US
Paresh Thakker - Boston MA, US
Fuk-Wah Sum - Pomona NY, US
Mark L. Behnke - Somerville MA, US
Baihua Hu - Audubon PA, US
James D. Clark - Acton MA, US
Wei Li - Acton MA, US
Valerie Clerin - Watertown MA, US
Suzana Marusic - Reading MA, US
Kevin Pong - Robbinsville NJ, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/54
US Classification:
5142282, 514374, 514375, 514381, 514386, 514406, 514414, 5142335, 51425409, 514256, 514365, 514339, 514345, 544 582, 544143, 544333, 544373, 546 16, 546201, 5462774, 546115
Abstract:
This invention provides methods for the use of substituted indole compounds of the general formula:.

Methods For The Use Of Inhibitors Of Cytosolic Phospholipase A2

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US Patent:
7906548, Mar 15, 2011
Filed:
Aug 11, 2009
Appl. No.:
12/539074
Inventors:
John C. McKew - Arlington MA, US
Steve Y. Tam - Wellesley MA, US
Katherine L. Lee - West Newton MA, US
Lihren Chen - Cambridge MA, US
Paresh Thakker - Boston MA, US
Fuk-Wah Sum - Pomona NY, US
Mark L. Behnke - Somerville MA, US
Baihua Hu - Audubon PA, US
James D. Clark - Acton MA, US
Wei Li - Acton MA, US
Valerie Clerin - Watertown MA, US
Suzana Marusic - Reading MA, US
Kevin Pong - Robbinsville NJ, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A01N 43/38
US Classification:
514415
Abstract:
This invention provides methods for the use of substituted indole compounds of the general formula:.

Inhibitors Of Cytosolic Phospholipase A

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US Patent:
8283373, Oct 9, 2012
Filed:
Jun 19, 2009
Appl. No.:
12/488182
Inventors:
John C. McKew - Arlington MA, US
Katherine L. Lee - Newton MA, US
Lihren Chen - Bedford MA, US
Richard Vargas - Brighton MA, US
James D. Clark - Acton MA, US
Cara Williams - Methuen MA, US
Valerie Clerin - Watertown MA, US
Suzana Marusic - Reading MA, US
Kevin Pong - Robbinsville NJ, US
Assignee:
Pfizer Inc. - New York NY
International Classification:
A61K 31/404
US Classification:
514415
Abstract:
This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase Aenzymes (cPLA), more particularly including inhibitors of cytosolic phospholipase Aalpha enzymes (cPLAα). In some embodiments, the inhibitors have the Formula I:.

Expression Of The Cysteine Protease Legumain In Vascular And Inflammatory Diseases

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US Patent:
20070274987, Nov 29, 2007
Filed:
May 25, 2007
Appl. No.:
11/806000
Inventors:
Valerie Clerin - Watertown MA, US
Heather Shih - Andover MA, US
Kathleen Shields - Harvard MA, US
Jeffrey Feldman - Arlington MA, US
Gustave Hebert - Arlington MA, US
Debra Pittman - Windham NH, US
Nanhua Deng - Brookline MA, US
International Classification:
A61K 39/395
A61K 38/17
C07H 21/04
A61K 39/00
C07K 14/705
C07K 16/28
US Classification:
424133100, 435069100, 435320100, 435325000, 530395000, 514008000, 536023500, 530388220
Abstract:
The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing vascular disorders/diseases and inflammatory disorders/diseases.

Methods For The Use Of Inhibitors Of Cytosolic Phospholipase A2 In The Treatment Of Thrombosis

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US Patent:
20080009485, Jan 10, 2008
Filed:
May 25, 2007
Appl. No.:
11/807341
Inventors:
Valerie Clerin - Watertown MA, US
Thomas Smith - Arlington MA, US
Katherine Lee - West Newton MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/54
A61K 31/405
A61K 31/495
A61P 9/00
A61K 31/5375
US Classification:
514228200, 514231500, 514254090, 514415000
Abstract:
This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds in the treating or preventing thrombosis in a mammal, or preventing progression of symptoms of thrombosis.

Inhibitors Of Cytosolic Phospholipase A2

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US Patent:
20100029645, Feb 4, 2010
Filed:
Jun 19, 2009
Appl. No.:
12/488020
Inventors:
John C. McKew - Arlington MA, US
Katherine L. Lee - Newton MA, US
Lihren Chen - Bedford MA, US
Richard Vargas - Brighton MA, US
James D. Clark - Acton MA, US
Cara Williams - Methuen MA, US
Valerie Clerin - Watertown MA, US
Suzana Marusic - Reading MA, US
Kevin Pong - Robbinsville NJ, US
International Classification:
A61K 31/5377
C07D 209/04
C07D 403/02
C07D 413/02
A61K 31/405
A61K 31/497
A61P 29/00
A61P 19/02
A61P 25/00
A61P 7/02
US Classification:
5142352, 548491, 544373, 544143, 514415, 51425409
Abstract:
This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase Aenzymes (cPLA), more particularly including inhibitors of cytosolic phospholipase Aalpha enzymes (cPLAα). In some embodiments, the inhibitors have the Formula I:wherein the constituent variables are as defined herein.

Expression Of The Cysteine Protease Legumain In Vascular And Inflammatory Diseases

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US Patent:
20100158924, Jun 24, 2010
Filed:
Feb 4, 2010
Appl. No.:
12/700178
Inventors:
Valerie Clerin - Watertown MA, US
Heather H. Shih - Andover MA, US
Kathleen Shields - Harvard MA, US
Jeffrey Feldman - Arlington MA, US
Gustave T. Hebert - Arlington MA, US
Debra D. Pittman - Windham NH, US
Nanhua Dan Deng - Brookline MA, US
Assignee:
Wyeth, LLC - Madison NJ
International Classification:
A61K 39/395
C07H 21/00
C07K 14/00
C07K 16/00
A61K 31/7052
A61K 38/02
C12Q 1/37
A61P 9/00
A61P 29/00
US Classification:
4241581, 536 231, 530350, 5303891, 514 44 A, 514 2, 435 24
Abstract:
The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing vascular disorders/diseases and inflammatory disorders/diseases.
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Valerie M Clerin from Lexington, MA, age ~52 Get Report