William D Sanders

20130072995, Mar 21, 2013

Jul 11, 2012

13/547035

Terrance Ransbury - Chapel Hill NC, US
Richard S. Stack - Chapel Hill NC, US
William E. Sanders - Chapel Hill NC, US
Stephen C. Masson - Raleigh NC, US

A61N 1/36

607 2

A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning within a pulmonary artery. Each therapy element is carried on a corresponding elongate flexible shaft. One of the shafts is slidably received within a lumen of the other so that the second therapy element may be advanced within the body relative to the first. A stimulator energizes the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery. For treatment of heart failure, the first nerve fiber may be a vagus nerve and the second nerve fiber may be a sympathetic nerve fiber.

20130072997, Mar 21, 2013

Jul 11, 2012

13/547031

William E. Sanders - Chapel Hill NC, US
Stephen C. Masson - Raleigh NC, US
Terrance Ransbury - Chapel Hill NC, US
Richard S. Stack - Chapel Hill NC, US

A61N 1/36

607 18, 607 9, 607 23

A method of treating autonomic imbalance in a patient includes energizing a first therapeutic element disposed in a superior vena cava of the patient to deliver therapy to a parasympathetic nerve fiber (e.g. vagus nerve), and energizing a second therapeutic element disposed within the superior vena cava to deliver therapy to a sympathetic cardiac nerve fiber. A neuromodulation system includes a parasympathetic therapy element adapted for positioning within a blood vessel, a sympathetic therapy element adapted for positioning within the blood vessel; and a stimulator to energize the parasympathetic therapy element to deliver parasympathetic therapy to a parasympathetic nerve fiber disposed external to the blood vessel and energize the sympathetic therapy element within the blood vessel to deliver sympathetic therapy to a sympathetic nerve fiber disposed external to the blood vessel. The therapy decreases the patient's heart rate and elevates or maintains the blood pressure of the patient.

20140052208, Feb 20, 2014

Oct 28, 2013

14/064544

William E Sanders - Chapel Hill NC, US
Richard S Stack - Chapel Hill NC, US
Colleen Stack - Chapel Hill NC, US

Synecor LLC - Chapel Hill NC

A61N 1/362
A61N 1/05

607 14, 607122

A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan-Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.

20220244154, Aug 4, 2022

Apr 18, 2022

17/722887

- Research Triangle Park NC, US
William SANDERS - Research Triangle Park NC, US
Yan ZHANG - Research Triangle Park NC, US
Robert Ernest Troxler - Research Triangle Park NC, US

G01N 3/12
G01N 3/06
G01N 3/14
G01N 3/18
G05B 6/02

An apparatus for testing paving samples includes a base that includes a paving sample tray about the cabinet and configured for translation relative to the cabinet. A roller is configured for imparting compressive forces to a sample carried by the sample tray. An arm is configured for moving the roller from a stowed position to an in-use position where the roller contacts the sample. A cylinder assembly having a piston therein supplies pressure forces to the arm to move the arm from the stowed position to the in-use position, wherein a depth of travel of the arm is limited by the sample. As the sample is compressed, the depth of travel increases. A measurement device is in communication with the cylinder for determining an amount of travel of the arm to thus determine an amount of compression of the sample.

20230029466, Feb 2, 2023

Jul 27, 2021

17/443581

WILLIAM SANDERS - GARNER NC, US
Kizzy Sanders - GARNER NC, US

A61F 5/01
A61F 7/02

The Pocketed Compression sheath is polyester compressive material formed into an open-ended sheath. Squares of the same type of polyester material are sewn onto the sides of the open-ended sheath to form pockets. The sheath is intended to be slid onto an extremity such as foot. Figure B illustrates a larger version intended to be utilized for the mid to upper leg. The pockets are intended to be place holders for heating packs or ice packs to help minimize swelling and pain in muscles and joints.

20200206512, Jul 2, 2020

Aug 8, 2019

16/536274

- Chapel Hill NC, US
Terrance Ransbury - Chapel Hill NC, US
Richard S. Stack - Chapel Hill NC, US
William E. Sanders - Chapel Hill NC, US

Interventional Autonomics Corporation - Chapel Hill NC

A61N 1/36
A61N 1/05

A method of treating a patient having a blood pressure comprises delivering neuromodulation therapy to sustain or increase the blood pressure. The neuromodulation therapy includes placing a sympathetic therapy electrode in a posterior portion of a blood vessel and stimulating at least one extravascular cardiac sympathetic nerve fiber using said electrode.

20190331571, Oct 31, 2019

Jul 8, 2019

16/505210

- Research Triangle Park NC, US
William SANDERS - Research Triangle Park NC, US
Yan ZHANG - Research Triangle Park NC, US
Robert Ernest Troxler - Research Triangle Park NC, US

G01N 3/12
G01N 3/14
G01N 3/06
G01N 3/18
G05B 6/02

An apparatus for testing paving samples includes a base that includes a paving sample tray about the cabinet and configured for translation relative to the cabinet. A roller is configured for imparting compressive forces to a sample carried by the sample tray. An arm is configured for moving the roller from a stowed position to an in-use position where the roller contacts the sample. A cylinder assembly having a piston therein supplies pressure forces to the arm to move the arm from the stowed position to the in-use position, wherein a depth of travel of the arm is limited by the sample. As the sample is compressed, the depth of travel increases. A measurement device is in communication with the cylinder for determining an amount of travel of the arm to thus determine an amount of compression of the sample.

20180117305, May 3, 2018

Dec 27, 2017

15/855991

- Chapel Hill NC, US
Richard S. Stack - Chapel Hill NC, US
William E. Sanders - Chapel Hill NC, US
Stephen C. Masson - Raleigh NC, US

Interventional Autonomics Corporation - Chapel Hill NC

A61N 1/05
A61N 1/365
A61N 1/36
A61B 5/0215

A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning within a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft. One of the first and second shafts is slidably received within a lumen of the other of the first and second shafts—so that the second therapy element may be advanced within the body relative to the first therapy element. A stimulator is configured to energize the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery. For treatment of heart failure, the first nerve fiber may be a vagus nerve and the second nerve fiber may be a sympathetic nerve fiber.