US Patent:
20100144608, Jun 10, 2010
Inventors:
Yiyin Ku - Buffalo Grove IL, US
Keith F. McDaniel - Wauconda IL, US
Hui-Ju Chen - Grayslake IL, US
Jason P. Shanley - Chicago IL, US
Dale J. Kempf - Libertyville IL, US
David J. Grampovnik - Waukegan IL, US
Ying Sun - Waltham MA, US
Dong Liu - Newton MA, US
Yonghua Gai - North Grafton MA, US
Yat Sun Or - Watertown MA, US
Seble H. Wagaw - Evanston IL, US
Ken Engstrom - Mundelein IL, US
Tim Grieme - Chicago IL, US
Ahmad Sheikh - Deerfield IL, US
Jianzhang Mei - Lake Forest IL, US
International Classification:
A61K 38/12
C07D 487/04
A61P 31/12
Abstract:
The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.